Main Article: Runes#List
- Can regenerate up to Expression error: Unrecognized punctuation character "%".% of a unit's max health and max mana over its full duration.
- Can fully regenerate a unit's health and mana within 16.67 seconds.
- The buff disappears once the hero is at full health and mana.
- Damage greater than 0 from any player (including allies and self) or Roshan dispels the effect.
- Does not get dispelled by damage flagged as HP Removal.
- The buff is applied to invulnerable and hidden units.
- The buff of multiple Regeneration Runes does not stack, but refreshes the duration instead.
{{#set:
| title = Regeneration Rune
| image = File:Bottle (Regeneration) icon.png
}}