- Anti-Mage's burns Medusa's mana easily, especially when coupled with a .
- Can easily initiate on Medusa with , burning her mana or forcing her to use Stone Gaze.
- is effective against Medusa's big mana pool and mana usage, presenting a huge hazard to Medusa's allies around her since her Mana Shield still gives her some protection if she has mana.
- Unlike other illusion heroes, won't be instantly destroyed by Stone Gaze since it is considered a clone and not an illusion.
- He can use either his own or his double's to bypass the spellblock from Linken's Sphere, using the leftover Flux + to slow Medusa's move speed to a crawl.
- Arc Warden has a farming advantage with double , and can generally bully Medusa with other items that benefit from duplication.
- His Spell immunity. will leave Medusa defenseless after he's done, if his teammates can provide cover for him or he initiates at the right time by
- will give Medusa a dire time to clear horde of small spiderlings or retaliate Broodmother herself.
- will allow broodmother to pick her own fights and sometimes slip away to ambush Medusa.
- is a large mana burn nuke which can hit Medusa's Mana shield with enough damage to lose even more mana.
- disarms Medusa's ability to deal pseudo-AOE damage during teamfights.
- allows the opposing team to repeatedly stun Medusa in short succession, preventing her from successfully casting her ultimate due to its long cast time.
- can drain her current mana, draining away her effective health in a sneaky way.
- will keep Medusa busy after she got hit by .
- Level 4 burns 38,5% of Medusa's mana every 4 seconds if Medusa only increases her mana pool with intelligence. Additionally, 60% of the damage gets mitigated by Mana Shield, burning even more mana.
- Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's if he's within range of Medusa's abilities and isn't invisible.
- Medusa lacks single target damage, making Nyx with extremely hard to deal with if Medusa is the team's main damage source.
- Phantom Lancer with will very quickly burn Medusa's mana, making Mana Shield significantly less effective.
- invulnerability can be used to dodge Medusa's petrification from Stone Gaze, as well as Mystic Snake. 's 1 second
- Phantom Lancer's illusions outnumber Medusa's targets from Split Shot, likely shielding your team in the process.
- will cause an unfriendly area for Medusa, draining her mana.
- He won't be around waiting for Medusa to Stone Gaze and pin him until she bears a true sight.
- With , Riki will silence and catch Medusa in a surprise with high miss chance flushing her from positions easily in team fights.
- He can still deal huge amount of damage through via backstabs, drying out Medusa's protection in a whim at random occassions.
- Medusa is especially vulnerable to , as both strength and intelligence contribute to her effective HP, while agility contributes to her damage.
- when timed right can be used to dispel Stone Gaze right after it petrifies Slark, allowing him to keep attacking Medusa throughout the duration.
- Sniper can outrange both Medusa's arrows and Stone Gaze, allowing him to focus her down during a teamfight.
- Ursa's status resistance from will ignore Medusa's gaze.
- Ursa can stack damage with easily against her Mana Shield in a prolonged team match.
- Other heroes with mana burning or manipulating abilities will make Medusa much less tanky: , , .
- Heroes that build or can fit it well into their item build will also make Medusa much less tanky: , , , , , , .
- Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: , , .
- In theory Medusa counters all melee heroes, even though that is not the case with Mana-burning heroes and heroes with escapes although Medusa can outfight even Anti-Mage if he gets petrified.
- burns away the mana Medusa needs for Mana Shield also its active ability will slow her down.
- provides mana burning summons, and Split Shot makes Medusa especially vulnerable to getting hit with Last Will.
- activation for a disengage can make her regret any auto attacks or Mystic Snake cast.
- disarms Medusa for a long 5 seconds.
- slows her healing and lifesteal effects, eats away her mana pool slowly and can sustain the effects if it has stacks.
- removes a huge chunk of armor and adds an attack speed debuff. Slows her damage output and movement in team fights allows her to get focused also dims her durability.
- ignores her capable evasion abilities coming from items and puts a safe distance for disengaging.
- ignores evasion on debuffed targets and hits the 30% chunk of damage sum along the debuff at the end of its duration.
- has a 75% chance to add bonus damage and true strike for ignoring evasion.
- Enchantress often has a small army of neutral creeps, allowing Medusa to hit her with a later bounce of her Mystic Snake.
- Untouchable is ignored by secondary attacks from Split Shot.
- Lifestealer's low mobility makes him easy to kite.
- Stone Gaze pierces , wasting its cooldown and making Lifestealer unable to fight.
- Mana Shield tanks most of the damage from Reaper's Scythe; with sufficient mana, the kill threshold drops to 15%/17%/19% health (before reductions).
- Heartstopper Aura does not chip away at Medusa's mana, this makes it not a threat as it deals damage based on current health.
- Necrophos has a movement speed equal to Medusa, and is easy to chase down with a slowing item in Medusa's inventory.
- Stone Gaze allows Medusa to easily kite and kill Sven.
- Mystic Snake eats away at Sven's small mana pool.
- Mana Shield negates much of Sven's burst damage.
- Split Shot can destroy Tombstone Zombies and Tombstone itself while still damaging heroes.
- Mana Shield reduces the impact of Decay and Flesh Golem's Plague Aura.
- Can be easily petrified despite his speed.
- Summoned wolves will be targeted by Split Shot or Mystic Snake
- Mana Shield makes Medusa harder to kill with Enigma's Black Hole and Pulse combo.
- Medusa's Split Shot can kill Demonic Conversion creeps easier and Mystic Snake bounces off from them.
- Stone Gaze makes it hard for Enigma to approach Medusa for a Black Hole.
- Poof won't damage Medusa and he can Gaze an entire flock of Meepos.
- Mystic Snake will easily become the bane of Meepo early game.
- Mystic Snake can harass Axe in lane and drain his small mana pool.
- Mana Shield reduces the effectiveness of Counter Helix.
- Stone Gaze makes it very difficult for Axe to pursue.
- Summoned gargoyles will give Medusa free target practice.
- Mana Shield will resist Soul Assumption instances without effort.
- Stone Gaze negates Dispersion's damage reduction and allows Medusa to kite Spectre.
- Spectre's small mana pool is depleted quickly by Mystic Snake.
- Split Shot can clear Haunt illusions quickly.
- Heroes that rely on summons. A few summons, such Lycan wolves allow Medusa to bounce her Mystic Snake between them to hit the hero for additional damage. Many weak summons, such as Visage force the group to tank Medusa's Split Shot.
- Heroes that rely on Black King Bar to survive teamfights.
Works well with...
- Berserker's Call can force enemies to face Medusa during her Stone Gaze.
- Deals area damage with ultimate and can stun/disable to cast Stone Gaze and make it easier to freeze enemy heroes.
- benefits Medusa's Mana Shield greatly, and also allows more liberal use of Mystic Snake.
- Stone Gaze slows enemies and stuns them for a duration. With correct timing, Keeper of the Light can land a fully-charged on multiple enemies.
- helps ensure enemies face Medusa when she casts Stone Gaze. Both ultimate abilities have a long duration, causing massive disruption in teamfights.
- further improves Medusa's tankiness
- forces an enemy to face Medusa during Stone Gaze
- can be used to force enemy meele heroes to scatter away from Medusa
- The protection offered by Stone Gaze allows Phoenix to place its much more aggressively
- helps to recover Medusa's HP
- The upgrade for Supernova allows Phoenix to save Medusa from a dire situation, and allows Medusa to fully recover her HP and MP, provided that the egg lasts 6 seconds
- can be used to protect Medusa if she's getting overwhelmed by physical damage
- As long as Medusa has full HP, Pugna can cast on her to restore her mana
- During teamfights, casting Disruption upon Medusa creates a pair of illusions with Split Shot and 80% of her base damage.
- Shadow Demon can stack 2-3 jungle camps at the same time, speeding up Medusa's farming phase.
- makes it easier for Medusa to chase down enemy heroes fleeing from Stone Gaze
- Heroes that deal pure damage like Tinker's Aghanim Laser upgrade can give him enough time to cast it a couple of times or Outworld Devourer can deal the full damage of his Arcane Orb and stack a lot of intelligence for those 3 seconds of Stone Gaze
- Everyone with good physical damage and lock down for a good Stone Gaze
- Abilities that grant sustain or heroes with sustain to keep the enemy kited and distracted while Medusa slowly destroys them
- , , and restores both health and mana to Medusa, doubly effective as a sustain item since she can tank with Mana Shield.